PAHs are environmental contaminants prevelant at Superfund Sites and represent 3 top 10 most hazardous substances (ATSDR Priority List of Hazardous Substances). A major obstacle for regulator agencies is lack of human data. We will characterize uptake/elimination of BaP in humans at environmental levels and identify susceptible individuals. This provides critical data for health risk from environmental exposure to PAHs.
- Conduct the first pharmacokinetic study of BaP in humans.
- Conduct the first evaluation of the Relative Potency Factor approach to risk assessment for PAHs in human studies.
- Conduct the first assessment of gene-environment interactions in human at environmentally relevant levels of exposure to PAHs.
- Demonstrated that PAH mixtures are more potent skin carcinogens compared to benzo[a]pyrene than the Relative Potency Factor approach would predict.
- Tested, for the first time anywhere, PAH mixtures, including those collected from a Superfund site, as transplacental carcinogens. PAH mixtures caused development toxicities but were relatively poor transplacental carcinogens.
- David Williams, Leader, OSU
- William Baird, Co-Investigator, OSU
- Christiane Löhr, Co-Investigator, OSU
- Lisbeth Siddens, Sr. Research Asst, OSU
- Erin Madeen, graduate researcher, OSU