Objective

PAHs are environmental contaminants prevelant at Superfund Sites and represent 3 top 10 most hazardous substances (ATSDR Priority List of Hazardous Substances). A major obstacle for regulator agencies is lack of human data.  We will characterize uptake/elimination of BaP in humans at environmental levels and identify susceptible individuals. This provides critical data for health risk from environmental exposure to PAHs.

Activities
  • Conduct the first pharmacokinetic study of BaP in humans.
  • Conduct the first evaluation of the Relative Potency Factor approach to risk assessment for PAHs in human studies.
  • Conduct the first assessment of gene-environment interactions in human at environmentally relevant levels of exposure to PAHs.

Major Accomplishments
  • Demonstrated that PAH mixtures are more potent skin carcinogens compared to benzo[a]pyrene than the Relative Potency Factor approach would predict.
  • Tested, for the first time anywhere, PAH mixtures, including those collected from a Superfund site, as transplacental carcinogens. PAH mixtures caused development toxicities but were relatively poor transplacental carcinogens.

People