Objective

Provide a centralized plan for management, analysis and integration of research data that will be utilized by several of our research projects and cores

Activities
  1. Statistics for experimental design, biomarker discovery and multivariate data analyses.
  2. Bioinformatics for reconstruction of regulatory pathways and cross-species extrapolations.
  3. Integrated data storage and management software that provides storage and tracking of raw experimental data along with important metadata (experimental conditions, sample characteristics, etc.).

Significance

The Research projects in this Center are collecting large amounts of molecular and chemical data to determine new toxicity endpoints for PAH mixtures, mechanism of action for these endpoints, and assessment of PAH mixtures and particulates through environmental exposure. Integration of traditional toxicity endpoints with high-throughput gene expression data and high-dimensional analytical chemistry data is essential for the identification of biomarkers of response and chemical fingerprints of exposure. The integration of real environmental exposure data with traditional toxicity testing ensures that our estimates of risk are grounded in realistic exposures, and our PBPK component in Project 2 ensures that these exposure estimates are accurately translated to humans.

The Statistics and Bioinformatics Core greatly enhances our Center by providing expert statistical and bioinformatics data analysis support and software solutions for data management and interpretation. The standardization of data analysis methods will ensure that the best methods are utilized and enhance the utility of such information in future risk assessments and regulatory decisions by regulatory agencies. The centralized data management organization also promotes data sharing across research projects and facilitates the publication of data to the NIEHS Chemical Effects in Biological Systems Knowledge Base for public availability of Program data. In addition, we are providing training to post-doctoral scientists and graduate students involved in the program who desire to learn the expert analysis methods needed for their projects.


Project-Generated Resources

Bioinformatics Resource Manager (BRM):The bioinformatics software updates are now available as web-based tools, which are freely available to the community without account registration.


People

Katrina Waters Profile Picture
Katrina Waters, Leader, PNNL

  • Elena Peterson, PNNL
  • Aaron Phillips, PNNL
  • Dennis Thomas, PNNL

Leveraging years of internal investments in bioinformatics infrastructure diagram