Susan Tilton
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Project Leader
The Tilton Lab uses molecular and computational tools to predict toxicity of chemical contaminants in the environment. Her research program develops and applies advanced cell culture techniques and organotypic models to explore mechanisms of toxicity and disease in human systems with a primary goal to use these new approach methodologies for improved translation and risk assessment. Her lab is particularly interested in identifying environmental health outcomes associated with inhaled pollutants and chemical mixtures from urban environments, contaminated sites and wildfires.
Associated Research
External Profile
Recent Superfund Publications
2025
Building a predictive model for polycyclic aromatic hydrocarbon dosimetry in organotypically cultured human bronchial epithelial cells using benzo[ a]pyrene Toxicology Reports 2025 PubMed PMC12517105
Utilization of the CometChip assay for detecting PAH-induced DNA bulky adducts in a 3D primary human bronchial epithelial cell model Toxicology 2025 PubMed PMC12356187
2024
Assessing susceptibility for polycyclic aromatic hydrocarbon toxicity in an in vitro 3D respiratory model for asthma. Front Toxicol 2024 PubMed PMC11066177
Modeling PAH Mixture Interactions in a Human In Vitro Organotypic Respiratory Model. Int J Mol Sci 2024 PubMed PMC11050152
2023
Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 2023 PubMed PMC10782561
Coupling Environmental Whole Mixture Toxicity Screening with Unbiased RNA-Seq Reveals Site-Specific Biological Responses in Zebrafish. Toxics 2023 PubMed PMC10053777
Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. Toxicol Appl Pharmacol 2023 PubMed PMC9946811
2022
Leveraging Multiple Data Streams for Prioritization of Mixtures for Hazard Characterization. Toxics 2022 PubMed PMC9699527
A Comparative Multi-System Approach to Characterizing Bioactivity of Commonly Occurring Chemicals. Int J Environ Res Public Health 2022 PubMed PMC8998123