TitleChemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy.
Publication TypeJournal Article
Year of Publication2021
AuthorsDoherty, BT, McRitchie, SL, Pathmasiri, WW, Stewart, DA, Kirchner, D, Anderson, KA, Gui, J, Madan, JC, Hoen, AG, Sumner, SJ, Karagas, MR, Romano, ME
JournalJ Expo Sci Environ Epidemiol
Date Published2021 Oct 26
ISSN1559-064X
Abstract

BACKGROUND: Metabolomics is a promising method to investigate physiological effects of chemical exposures during pregnancy, with the potential to clarify toxicological mechanisms, suggest sensitive endpoints, and identify novel biomarkers of exposures.

OBJECTIVE: Investigate the influence of chemical exposures on the maternal plasma metabolome during pregnancy.

METHODS: Data were obtained from participants (n = 177) in the New Hampshire Birth Cohort Study, a prospective pregnancy cohort. Chemical exposures were assessed via silicone wristbands worn for one week at ~13 gestational weeks. Metabolomic features were assessed in plasma samples obtained at ~24-28 gestational weeks via the Biocrates AbsoluteIDQ® p180 kit and nuclear magnetic resonance (NMR) spectroscopy. Associations between chemical exposures and plasma metabolomics were investigated using multivariate modeling.

RESULTS: Chemical exposures predicted 11 (of 226) and 23 (of 125) metabolomic features in Biocrates and NMR, respectively. The joint chemical exposures did not significantly predict pathway enrichment, though some individual chemicals were associated with certain amino acids and related metabolic pathways. For example, N,N-diethyl-m-toluamide was associated with the amino acids glycine, L-glutamic acid, L-asparagine, and L-aspartic acid and enrichment of the ammonia recycling pathway.

SIGNIFICANCE: This study contributes evidence to the potential effects of chemical exposures during pregnancy upon the endogenous maternal plasma metabolome.

DOI10.1038/s41370-021-00394-6
Alternate JournalJ Expo Sci Environ Epidemiol
PubMed ID34702988
Grant ListP30 ES030287 / ES / NIEHS NIH HHS / United States
R25 CA134286 / CA / NCI NIH HHS / United States
U24 OD023382 / OD / NIH HHS / United States
U2C OD023375 / OD / NIH HHS / United States