| Title | Developmental Toxicity Assessment Using Zebrafish-Based High-Throughput Screening. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Dasgupta, S, Simonich, MT, Tanguay, RL |
| Journal | Methods Mol Biol |
| Volume | 2707 |
| Pagination | 71-82 |
| Date Published | 2024 |
| ISSN | 1940-6029 |
| Keywords | Animals, Hazardous Substances, High-Throughput Screening Assays, Laboratories, Policy, Zebrafish |
| Abstract | Zebrafish-based high-throughput screening has been extensively used to study toxicological profiles of individual chemicals and mixtures, identify novel toxicants, and study modes of action to prioritize chemicals for further testing and policy decisions. Within this chapter, we describe a protocol for automated zebrafish developmental high-throughput screening in our laboratory, with emphasis on exposure setups, morphological and behavioral readouts, and quality control. |
| DOI | 10.1007/978-1-0716-3401-1_4 |
| Alternate Journal | Methods Mol Biol |
| PubMed ID | 37668905 |
| Grant List | P42 ES016465 / ES / NIEHS NIH HHS / United States |
