TitleIntegrated Framework for Identifying Toxic Transformation Products in Complex Environmental Mixtures.
Publication TypeJournal Article
Year of Publication2017
AuthorsChibwe, L, Titaley, IA, Hoh, E, Simonich, SLMassey
JournalEnviron Sci Technol Lett
Volume4
Issue2
Pagination32-43
Date Published2017 Feb 14
ISSN2328-8930
Abstract

Complex environmental mixtures consist of hundreds to thousands of unknown and unregulated organic compounds that may have toxicological relevance, including transformation products (TPs) of anthropogenic organic pollutants. Non-targeted analysis and suspect screening analysis offer analytical approaches for potentially identifying these toxic transformation products. However, additional tools and strategies are needed in order to reduce the number of chemicals of interest and focus analytical efforts on chemicals that may pose risks to humans and the environment. This brief review highlights recent developments in this field and suggests an integrated framework that incorporates complementary instrumental techniques, computational chemistry, and toxicity analysis, for prioritizing and identifying toxic TPs in the environment.

DOI10.1021/acs.estlett.6b00455
Alternate JournalEnviron Sci Technol Lett
PubMed ID35600207
PubMed Central IDPMC9119311
Grant ListP01 ES021921 / ES / NIEHS NIH HHS / United States
P30 ES000210 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States