TitlePharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction.
Publication TypeJournal Article
Year of Publication2018
AuthorsHummel, JM, Madeen, EP, Siddens, LK, Uesugi, SL, McQuistan, TJ, Anderson, KA, Turteltaub, KW, Ognibene, TJ, Bench, G, Krueger, SK, Harris, S, Smith, JN, Tilton, SC, Baird, WM, Williams, DE
JournalFood Chem Toxicol
Volume115
Pagination136-147
Date Published2018 May
ISSN1873-6351
KeywordsAdult, Aged, Animals, Benzo(a)pyrene, Carbon Radioisotopes, Carcinogens, Cooking, Female, Fish Products, Food Safety, Humans, Male, Middle Aged, Polycyclic Aromatic Hydrocarbons, Salmon, Young Adult
Abstract

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is a known human carcinogen. In non-smoking adults greater than 95% of BaP exposure is through diet. The carcinogenicity of BaP is utilized by the U.S. EPA to assess relative potency of complex PAH mixtures. PAH relative potency factors (RPFs, BaP = 1) are determined from high dose animal data. We employed accelerator mass spectrometry (AMS) to determine pharmacokinetics of [C]-BaP in humans following dosing with 46 ng (an order of magnitude lower than human dietary daily exposure and million-fold lower than animal cancer models). To assess the impact of co-administration of food with a complex PAH mixture, humans were dosed with 46 ng of [C]-BaP with or without smoked salmon. Subjects were asked to avoid high BaP-containing diets and a 3-day dietary questionnaire given to assess dietary exposure prior to dosing and three days post-dosing with [C]-BaP. Co-administration of smoked salmon, containing a complex mixture of PAHs with an RPF of 460 ng BaP, reduced and delayed absorption. Administration of canned commercial salmon, containing very low amounts of PAHs, showed the impacts on pharmacokinetics were not due to high amounts of PAHs but rather a food matrix effect.

DOI10.1016/j.fct.2018.03.003
Alternate JournalFood Chem. Toxicol.
PubMed ID29518434
PubMed Central IDPMC5935529
Grant ListP41 GM103483 / GM / NIGMS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
R01 ES028600 / ES / NIEHS NIH HHS / United States
T32 ES007060 / ES / NIEHS NIH HHS / United States