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In the News
Center Publications
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Susan C Tilton
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Journal Article
Curtis LR
,
Bravo CF
,
Bayne CJ
,
Tilton F
,
Arkoosh MR
,
Lambertini E
, et al.
.
Transcriptional changes in innate immunity genes in head kidneys from Aeromonas salmonicida-challenged rainbow trout fed a mixture of polycyclic aromatic hydrocarbons.
Ecotoxicol Environ Saf. 2017 ;142:157-163.
PubMed
Madeen EP
,
Siddens LK
,
Uesugi S
,
McQuistan TJ
,
Corley RA
,
Smith JN
, et al.
.
Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing.
Toxicol Appl Pharmacol. 2019 ;364:97-105.
PubMed
Geier MC
,
D Minick J
,
Truong L
,
Tilton SC
,
Pande P
,
Anderson KA
, et al.
.
Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish.
Toxicol Appl Pharmacol. 2018 ;354:115-125.
PubMed
Truong L
,
Tilton SC
,
Zaikova T
,
Richman E
,
Waters KM
,
Hutchison JE
, et al.
.
Surface functionalities of gold nanoparticles impact embryonic gene expression responses.
Nanotoxicology. 2013 ;7(2):192-201.
PubMed
Goodale BC
,
Tilton SC
,
Corvi MM
,
Wilson G
,
Janszen DB
,
Anderson KA
, et al.
.
Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish.
Toxicol Appl Pharmacol. 2013 ;272(3):656-70.
PubMed
Garcia GR
,
Shankar P
,
Dunham CL
,
Garcia A
,
La Du JK
,
Truong L
, et al.
.
Signaling Events Downstream of AHR Activation That Contribute to Toxic Responses: The Functional Role of an AHR-Dependent Long Noncoding RNA ( slincR) Using the Zebrafish Model.
Environ Health Perspect. 2018 ;126(11):117002.
PubMed
Franzosa JA
,
Bugel SM
,
Tal TL
,
La Du JK
,
Tilton SC
,
Waters KM
, et al.
.
Retinoic acid-dependent regulation of miR-19 expression elicits vertebrate axis defects.
FASEB J. 2013 ;27(12):4866-76.
PubMed
Siddens LK
,
Larkin A
,
Krueger SK
,
Bradfield CA
,
Waters KM
,
Tilton SC
, et al.
.
Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse.
Toxicol Appl Pharmacol. 2012 ;264(3):377-86.
PubMed
Hummel JM
,
Madeen EP
,
Siddens LK
,
Uesugi S
,
McQuistan TJ
,
Anderson KA
, et al.
.
Pharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction.
Food Chem Toxicol. 2018 ;115:136-147.
PubMed
Nguyen HH
,
Tilton SC
,
Kemp CJ
,
Song M
.
Nonmonotonic Pathway Gene Expression Analysis Reveals Oncogenic Role of p27/Kip1 at Intermediate Dose.
Cancer Inform. 2017 ;16:1176935117740132.
PubMed
Tal TL
,
Franzosa JA
,
Tilton SC
,
Philbrick KA
,
Iwaniec UT
,
Turner RT
, et al.
.
MicroRNAs control neurobehavioral development and function in zebrafish.
FASEB J. 2012 ;26(4):1452-61.
PubMed
Tilton SC
,
Siddens LK
,
Krueger SK
,
Larkin A
,
Löhr CV
,
Williams DE
, et al.
.
Mechanism-Based Classification of PAH Mixtures to Predict Carcinogenic Potential.
Toxicol Sci. 2015 ;146(1):135-45.
PubMed
Goodale BC
,
La Du JK
,
Tilton SC
,
Sullivan CM
,
Bisson WH
,
Waters KM
, et al.
.
Ligand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs.
Toxicol Sci. 2015 ;147(2):397-411.
PubMed
Saili KS
,
Tilton SC
,
Waters KM
,
Tanguay RL
.
Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17β-estradiol in embryonic zebrafish.
Reprod Toxicol. 2013 ;38:89-101.
PubMed
Chen J
,
Huang C
,
Truong L
,
La Du JK
,
Tilton SC
,
Waters KM
, et al.
.
Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish.
Toxicology. 2012 ;302(2-3):129-39.
PubMed
Chen J
,
Tanguay RL
,
Tal TL
,
Gai Z
,
Ma X
,
Bai C
, et al.
.
Early life perfluorooctanesulphonic acid (PFOS) exposure impairs zebrafish organogenesis.
Aquat Toxicol. 2014 ;150:124-32.
PubMed
Siddens LK
,
Bunde KL
,
Harper TA
,
McQuistan TJ
,
Löhr CV
,
Bramer LM
, et al.
.
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
Toxicol Appl Pharmacol. 2015 ;287(2):149-160.
PubMed
Chang Y
,
Siddens LK
,
Heine LK
,
Sampson DA
,
Yu Z
,
Fischer KA
, et al.
.
Comparative mechanisms of PAH toxicity by benzo[a]pyrene and dibenzo[def,p]chrysene in primary human bronchial epithelial cells cultured at air-liquid interface.
Toxicol Appl Pharmacol. 2019 ;:114644.
PubMed
Chang Y
,
Huynh CThanh Thu
,
Bastin KM
,
Rivera BN
,
Siddens LK
,
Tilton SC
.
Classifying polycyclic aromatic hydrocarbons by carcinogenic potency using in vitro biosignatures.
Toxicol In Vitro. 2020 ;69:104991.
PubMed
Tilton SC
,
Tal TL
,
Scroggins SM
,
Franzosa JA
,
Peterson ES
,
Tanguay RL
, et al.
.
Bioinformatics Resource Manager v2.3: an integrated software environment for systems biology with microRNA and cross-species analysis tools.
BMC Bioinformatics. 2012 ;13:311.
PubMed
Brown J
,
Phillips AR
,
Lewis DA
,
Mans M-A
,
Chang Y
,
Tanguay RL
, et al.
.
Bioinformatics Resource Manager: a systems biology web tool for microRNA and omics data integration.
BMC Bioinformatics. 2019 ;20(1):255.
PubMed
Garland MA
,
Geier MC
,
Bugel SM
,
Shankar P
,
Dunham CL
,
Brown J
, et al.
.
Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes.
Toxicol Sci. 2020 ;.
PubMed
Larkin A
,
Siddens LK
,
Krueger SK
,
Tilton SC
,
Waters KM
,
Williams DE
, et al.
.
Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin.
Toxicol Appl Pharmacol. 2013 ;267(2):192-9.
PubMed
Ehrlich AK
,
Pennington J
,
Tilton SC
,
Wang X
,
Marshall NB
,
Rohlman D
, et al.
.
AhR activation increases IL-2 production by alloreactive CD4 T cells initiating the differentiation of mucosal-homing Tim3 Lag3 Tr1 cells.
Eur J Immunol. 2017 ;47(11):1989-2001.
PubMed