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In the News
Center Publications
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2019
Stoddard EG
,
Killinger BJ
,
Nag S
,
Martin J
,
Corley RA
,
Smith JN
, et al.
.
Benzo[ a]pyrene Induction of Glutathione S-Transferases: An Activity-Based Protein Profiling Investigation.
Chem Res Toxicol. 2019 ;32(6):1259-1267.
PubMed
Brown J
,
Phillips AR
,
Lewis DA
,
Mans M-A
,
Chang Y
,
Tanguay RL
, et al.
.
Bioinformatics Resource Manager: a systems biology web tool for microRNA and omics data integration.
BMC Bioinformatics. 2019 ;20(1):255.
PubMed
2017
Stoddard EG
,
Killinger BJ
,
Nair RN
,
Sadler NC
,
Volk RF
,
Purvine SO
, et al.
.
Activity-Based Probes for Isoenzyme- and Site-Specific Functional Characterization of Glutathione S-Transferases.
J Am Chem Soc. 2017 ;139(45):16032-16035.
PubMed
Ehrlich AK
,
Pennington J
,
Tilton SC
,
Wang X
,
Marshall NB
,
Rohlman D
, et al.
.
AhR activation increases IL-2 production by alloreactive CD4 T cells initiating the differentiation of mucosal-homing Tim3 Lag3 Tr1 cells.
Eur J Immunol. 2017 ;47(11):1989-2001.
PubMed
Madeen EP
,
Löhr CV
,
You H
,
Siddens LK
,
Krueger SK
,
Dashwood RH
, et al.
.
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
Mol Carcinog. 2017 ;56(1):163-171.
PubMed
Smith JN
,
Mehinagic D
,
Nag S
,
Crowell SRitger
,
Corley RA
.
In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes.
Toxicol Lett. 2017 ;269:23-32.
PubMed
2015
Siddens LK
,
Bunde KL
,
Harper TA
,
McQuistan TJ
,
Löhr CV
,
Bramer LM
, et al.
.
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
Toxicol Appl Pharmacol. 2015 ;287(2):149-160.
PubMed
O'Connell SG
,
Kerkvliet NI
,
Carozza S
,
Rohlman D
,
Pennington J
,
Anderson KA
.
In vivo contaminant partitioning to silicone implants: Implications for use in biomonitoring and body burden.
Environ Int. 2015 ;85:182-8.
PubMed
Tilton SC
,
Siddens LK
,
Krueger SK
,
Larkin A
,
Löhr CV
,
Williams DE
, et al.
.
Mechanism-Based Classification of PAH Mixtures to Predict Carcinogenic Potential.
Toxicol Sci. 2015 ;146(1):135-45.
PubMed
Chatterjee P
,
Padmanarayana M
,
Abdullah N
,
Holman CL
,
La Du JK
,
Tanguay RL
, et al.
.
Otoferlin deficiency in zebrafish results in defects in balance and hearing: rescue of the balance and hearing phenotype with full-length and truncated forms of mouse otoferlin.
Mol Cell Biol. 2015 ;35(6):1043-54.
PubMed
2014
Crowell SRitger
,
Hanson-Drury S
,
Williams DE
,
Corley RA
.
In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes.
Toxicol Lett. 2014 ;228(1):48-55.
PubMed
2013
Larkin A
,
Siddens LK
,
Krueger SK
,
Tilton SC
,
Waters KM
,
Williams DE
, et al.
.
Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin.
Toxicol Appl Pharmacol. 2013 ;267(2):192-9.
PubMed
Shorey LE
,
Madeen EP
,
Atwell LL
,
Ho E
,
Löhr CV
,
Pereira CB
, et al.
.
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane.
Toxicol Appl Pharmacol. 2013 ;270(1):60-9.
PubMed
Crowell SRitger
,
Sharma AK
,
Amin SG
,
Soelberg JJ
,
Sadler NC
,
Wright AT
, et al.
.
Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice.
Toxicol Sci. 2013 ;135(1):48-62.
PubMed
2012
Siddens LK
,
Larkin A
,
Krueger SK
,
Bradfield CA
,
Waters KM
,
Tilton SC
, et al.
.
Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse.
Toxicol Appl Pharmacol. 2012 ;264(3):377-86.
PubMed
Shorey LE
,
Castro DJ
,
Baird WM
,
Siddens LK
,
Löhr CV
,
Matzke MM
, et al.
.
Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring.
Cancer Lett. 2012 ;317(1):49-55.
PubMed
2011
Crowell SRitger
,
Amin SG
,
Anderson KA
,
Krishnegowda G
,
Sharma AK
,
Soelberg JJ
, et al.
.
Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents.
Toxicol Appl Pharmacol. 2011 ;257(3):365-76.
PubMed
2010
O'Donnell EF
,
Saili KS
,
Koch DC
,
Kopparapu PR
,
Farrer D
,
Bisson WH
, et al.
.
The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor.
PLoS One. 2010 ;5(10).
PubMed
2009
Bisson WH
,
Koch DC
,
O'Donnell EF
,
Khalil SM
,
Kerkvliet NI
,
Tanguay RL
, et al.
.
Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands.
J Med Chem. 2009 ;52(18):5635-41.
PubMed
2006
Yu Z
,
Löhr CV
,
Fischer KA
,
Louderback MA
,
Krueger SK
,
Dashwood RH
, et al.
.
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor.
Cancer Res. 2006 ;66(2):755-62.
PubMed