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Application Of Single Cell Transcriptomics To Mechanistic Toxicology Peer Karmaus, Phd Staff Scientist National Institute of Environmental Health Sciences |
Toxicology testing has traditionally relied on rudimentary single endpoint outcomes. With the advent of single cell technologies, the biological unit of the cell can be interrogated at the mechanistic level. With recent advances in single cell transcriptomics, an unprecedented level of detail is now revealed on a per cell basis. These technologies now allow the assessment of population heterogeneity and the effect of chemical perturbation on cellular heterogeneity. Here Dr. Karmaus will discuss an example of applying single cell transcriptomics for evaluating the attenuation of T cell activation by atrazine.
Peer Karmaus is a Staff Scientist at the National Institute for Environmental Health Sciences and an Adjunct Assistant Professor at Michigan State University. His research focuses on how metabolism in innate and adaptive immune cells dictate cell fate and function.
