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Author Info
Siddens LK
2025
Colvin VC, Bastin KM, Siddens LK, Maier ML, Williams DE, Smith JN, Tilton SC Building a predictive model for polycyclic aromatic hydrocarbon dosimetry in organotypically cultured human bronchial epithelial cells using benzo[ a]pyrene Toxicology Reports 2025 PubMed PMC12517105
2023
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 2023 PubMed PMC10782561
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. Toxicol Appl Pharmacol 2023 PubMed PMC9946811
2022
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [(14)C]-BaP. Environ Int 2022 PubMed PMC8791557
2021
Maier ML, Siddens LK, Uesugi SL, Choi J, Leonard SW, Pennington JM, Tilton SC, Smith JN, Ho E, Chow HS, Nguyen BD, Kolluri SK, Williams DE 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. Drug Metab Dispos 2021 PubMed PMC8407664
2020
Chang Y, Huynh CT, Bastin KM, Rivera BN, Siddens LK, Tilton SC Classifying polycyclic aromatic hydrocarbons by carcinogenic potency using in vitro biosignatures. Toxicol In Vitro 2020 PubMed PMC7572825
2019
Chang Y, Siddens LK, Heine LK, Sampson DA, Yu Z, Fischer KA, Löhr CV, Tilton SC Comparative mechanisms of PAH toxicity by benzo[a]pyrene and dibenzo[def,p]chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol 2019 PubMed PMC6708476
Madeen EP, Siddens LK, Uesugi SL, Mcquistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene TJ, Turteltaub KW, Williams DE Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 2019 PubMed PMC6369707
2018
Hummel JM, Madeen EP, Siddens LK, Uesugi SL, Mcquistan TJ, Anderson KA, Turteltaub KW, Ognibene TJ, Bench G, Krueger SK, Harris S, Smith JN, Tilton SC, Baird WM, Williams DE Pharmacokinetics of [(14)C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food Chem Toxicol 2018 PubMed PMC5935529
2017
Madeen EP, Löhr CV, You H, Siddens LK, Krueger SK, Dashwood RH, Gonzalez FJ, Baird WM, Ho E, Bramer LM, Waters KM, Williams DE Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog 2017 PubMed PMC5457169
2015
Siddens LK, Bunde KL, Harper TA, Mcquistan TJ, Löhr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol 2015 PubMed PMC4689210
Tilton SC, Siddens LK, Krueger SK, Larkin AJ, Löhr CV, Williams DE, Baird WM, Waters KM Mechanism-Based Classification of PAH Mixtures to Predict Carcinogenic Potential. Toxicol Sci 2015 PubMed PMC4476464
2013
Larkin AJ, Siddens LK, Krueger SK, Tilton SC, Waters KM, Williams DE, Baird WM Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin. Toxicol Appl Pharmacol 2013 PubMed PMC3626406
2012
Siddens LK, Larkin AJ, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Löhr CV, Arlt VM, Phillips DH, Williams DE, Baird WM Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol 2012 PubMed PMC3483092