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Author Info
Williams DE
2025
Colvin VC, Bastin KM, Siddens LK, Maier ML, Williams DE, Smith JN, Tilton SC Building a predictive model for polycyclic aromatic hydrocarbon dosimetry in organotypically cultured human bronchial epithelial cells using benzo[ a]pyrene Toxicology Reports 2025 PubMed PMC12517105
2023
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 2023 PubMed PMC10782561
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. Toxicol Appl Pharmacol 2023 PubMed PMC9946811
2022
Pande P, Madeen EP, Williams DE, Crowell SR, Ognibene TJ, Turteltaub KW, Corley RA, Smith JN Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol 2022 PubMed PMC9264404
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [(14)C]-BaP. Environ Int 2022 PubMed PMC8791557
2021
Maier ML, Siddens LK, Uesugi SL, Choi J, Leonard SW, Pennington JM, Tilton SC, Smith JN, Ho E, Chow HS, Nguyen BD, Kolluri SK, Williams DE 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. Drug Metab Dispos 2021 PubMed PMC8407664
2019
Madeen EP, Siddens LK, Uesugi SL, Mcquistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene TJ, Turteltaub KW, Williams DE Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 2019 PubMed PMC6369707
2018
Hummel JM, Madeen EP, Siddens LK, Uesugi SL, Mcquistan TJ, Anderson KA, Turteltaub KW, Ognibene TJ, Bench G, Krueger SK, Harris S, Smith JN, Tilton SC, Baird WM, Williams DE Pharmacokinetics of [(14)C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food Chem Toxicol 2018 PubMed PMC5935529
2017
Madeen EP, Williams DE Environmental PAH exposure and male idiopathic infertility: a review on early life exposures and adult diagnosis. Rev Environ Health 2017 PubMed PMC5454023
Madeen EP, Löhr CV, You H, Siddens LK, Krueger SK, Dashwood RH, Gonzalez FJ, Baird WM, Ho E, Bramer LM, Waters KM, Williams DE Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog 2017 PubMed PMC5457169
2016
Madeen EP, Ognibene TJ, Corley RA, Mcquistan TJ, Henderson MC, Baird WM, Bench G, Turteltaub KW, Williams DE Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry. Chem Res Toxicol 2016 PubMed PMC5380438
Teeguarden JG, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Kile ML, Simonich SL, Stone DL, Tanguay RL, Waters KM, Harper SL, Williams DE Expanding on Successful Concepts, Models, and Organization. Environ Sci Technol 2016 PubMed
Teeguarden JG, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Kile ML, Simonich SL, Stone DL, Tanguay RL, Waters KM, Harper SL, Williams DE Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework. Environ Sci Technol 2016 PubMed PMC4854780
2015
Siddens LK, Bunde KL, Harper TA, Mcquistan TJ, Löhr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol 2015 PubMed PMC4689210
Tilton SC, Siddens LK, Krueger SK, Larkin AJ, Löhr CV, Williams DE, Baird WM, Waters KM Mechanism-Based Classification of PAH Mixtures to Predict Carcinogenic Potential. Toxicol Sci 2015 PubMed PMC4476464
Larkin AJ, Williams DE, Kile ML, Baird WM Developing a smartphone software package for predicting atmospheric pollutant concentrations at mobile locations. Comput J 2015 PubMed PMC4489712
Harper TA, Morré J, Lauer FT, Mcquistan TJ, Hummel JM, Burchiel SW, Williams DE Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS. Mutat Res Genet Toxicol Environ Mutagen 2015 PubMed PMC4395865
Madeen EP, Corley RA, Crowell SR, Turteltaub KW, Ognibene TJ, Malfatti M, Mcquistan TJ, Garrard M, Sudakin DL, Williams DE Human in Vivo Pharmacokinetics of [(14)C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Microdosing. Chem Res Toxicol 2015 PubMed PMC4303324
2014
Crowell SR, Hanson-drury S, Williams DE, Corley RA In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes. Toxicol Lett 2014 PubMed PMC4274170
2013
Crowell SR, Sharma AK, Amin SG, Soelberg JJ, Sadler NC, Wright AT, Baird WM, Williams DE, Corley RA Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice. Toxicol Sci 2013 PubMed PMC3748759
Shorey LE, Madeen EP, Atwell LL, Ho E, Löhr CV, Pereira CB, Dashwood RH, Williams DE Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. Toxicol Appl Pharmacol 2013 PubMed PMC3999518
Larkin AJ, Siddens LK, Krueger SK, Tilton SC, Waters KM, Williams DE, Baird WM Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin. Toxicol Appl Pharmacol 2013 PubMed PMC3626406
2012
Siddens LK, Larkin AJ, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Löhr CV, Arlt VM, Phillips DH, Williams DE, Baird WM Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol 2012 PubMed PMC3483092
Shorey LE, Castro DJ, Baird WM, Siddens LK, Löhr CV, Matzke MM, Waters KM, Corley RA, Williams DE Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring. Cancer Lett 2012 PubMed PMC3269513
Downs CA, Ostrander GK, Rougee L, Rongo T, Knutson S, Williams DE, Mendiola W, Holbrook J, Richmond RH The use of cellular diagnostics for identifying sub-lethal stress in reef corals. Ecotoxicology 2012 PubMed
Benninghoff AD, Orner GA, Buchner CH, Hendricks JD, Duffy AM, Williams DE Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout. Toxicol Sci 2012 PubMed PMC3243748
Fieber LA, Tanguay RL, Walter RB, Williams DE Aquatic animal models of human disease: selected papers from the 5th conference. Comp Biochem Physiol C Toxicol Pharmacol 2012 PubMed
2011
Crowell SR, Amin SG, Anderson KA, Krishnegowda G, Sharma AK, Soelberg JJ, Williams DE, Corley RA Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents. Toxicol Appl Pharmacol 2011 PubMed PMC3226888
2006
Yu Z, Loehr CV, Fischer KA, Louderback MA, Krueger SK, Dashwood RH, Kerkvliet NI, Pereira CB, Jennings-gee JE, Dance ST, Miller MS, Bailey GS, Williams DE In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res 2006 PubMed