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Author Info
Jordan Smith: Smith JN
2025
Colvin VC, Bastin KM, Siddens LK, Maier ML, Williams DE, Smith JN, Tilton SC Building a predictive model for polycyclic aromatic hydrocarbon dosimetry in organotypically cultured human bronchial epithelial cells using benzo[ a]pyrene Toxicology Reports 2025 PubMed PMC12517105
Gaither KA, Tyrrell KJ, Garcia WL, Anderson KA, Smith JN Human in vitro metabolism of an environmental mixture of polycyclic aromatic hydrocarbons (PAH) found at the Portland Harbor Superfund Site Toxicology Letters 2025 PubMed
Rude CI, Smith JN, Scott RP, Schultz KJ, Anderson KA, Tanguay RL A mixture parameterized biologically based dosimetry model to predict body burdens of polycyclic aromatic hydrocarbons in developmental zebrafish toxicity assays. Toxicol Sci 2025 PubMed PMC12118961
2024
Rude CI, Wilson LB, Ladu JK, Lalli PM, Colby SM, Schultz KJ, Smith JN, Waters KM, Tanguay RL Aryl hydrocarbon receptor-dependent toxicity by retene requires metabolic competence. Toxicol Sci 2024 PubMed PMC11514837
Gaither KA, Garcia WL, Tyrrell KJ, Wright AT, Smith JN Activity-Based Protein Profiling to Probe Relationships between Cytochrome P450 Enzymes and Early-Age Metabolism of Two Polycyclic Aromatic Hydrocarbons (PAHs): Phenanthrene and Retene. Chem Res Toxicol 2024 PubMed
2023
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 2023 PubMed PMC10782561
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. Toxicol Appl Pharmacol 2023 PubMed PMC9946811
2022
Smith JN, Gaither KA, Pande P Competitive Metabolism of Polycyclic Aromatic Hydrocarbons (PAHs): An Assessment Using In Vitro Metabolism and Physiologically Based Pharmacokinetic (PBPK) Modeling. Int J Environ Res Public Health 2022 PubMed PMC9323266
Garcia WL, Miller CJ, Lomas GX, Gaither KA, Tyrrell KJ, Smith JN, Brandvold KR, Wright AT Profiling How the Gut Microbiome Modulates Host Xenobiotic Metabolism in Response to Benzo[a]pyrene and 1-Nitropyrene Exposure. Chem Res Toxicol 2022 PubMed PMC9878584
Pande P, Madeen EP, Williams DE, Crowell SR, Ognibene TJ, Turteltaub KW, Corley RA, Smith JN Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol 2022 PubMed PMC9264404
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [(14)C]-BaP. Environ Int 2022 PubMed PMC8791557
2021
Stoddard EG, Nag SA, Martin J, Tyrrell KJ, Gibbins T, Anderson KA, Shukla AK, Corley RA, Wright AT, Smith JN Exposure to an Environmental Mixture of Polycyclic Aromatic Hydrocarbons Induces Hepatic Cytochrome P450 Enzymes in Mice. Chem Res Toxicol 2021 PubMed PMC8820091
Maier ML, Siddens LK, Uesugi SL, Choi J, Leonard SW, Pennington JM, Tilton SC, Smith JN, Ho E, Chow HS, Nguyen BD, Kolluri SK, Williams DE 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. Drug Metab Dispos 2021 PubMed PMC8407664
2019
Stoddard EG, Killinger BJ, Nag SA, Martin J, Corley RA, Smith JN, Wright AT Benzo[ a]pyrene Induction of Glutathione S-Transferases: An Activity-Based Protein Profiling Investigation. Chem Res Toxicol 2019 PubMed PMC7138413
Madeen EP, Siddens LK, Uesugi SL, Mcquistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene TJ, Turteltaub KW, Williams DE Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 2019 PubMed PMC6369707
2018
Stoddard EG, Volk RF, Carson JP, Ljungberg CM, Murphree TA, Smith JN, Sadler NC, Shukla AK, Ansong C, Wright AT Multifunctional Activity-Based Protein Profiling of the Developing Lung. J Proteome Res 2018 PubMed PMC6746415
Hummel JM, Madeen EP, Siddens LK, Uesugi SL, Mcquistan TJ, Anderson KA, Turteltaub KW, Ognibene TJ, Bench G, Krueger SK, Harris S, Smith JN, Tilton SC, Baird WM, Williams DE Pharmacokinetics of [(14)C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food Chem Toxicol 2018 PubMed PMC5935529
2017
Stoddard EG, Killinger BJ, Nair RN, Sadler NC, Volk RF, Purvine SO, Shukla AK, Smith JN, Wright AT Activity-Based Probes for Isoenzyme- and Site-Specific Functional Characterization of Glutathione S-Transferases. J Am Chem Soc 2017 PubMed PMC6279235
Smith JN, Mehinagic D, Nag SA, Crowell SR, Corley RA In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes. Toxicol Lett 2017 PubMed