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Author Info
Tilton SC
2025
Colvin VC, Bastin KM, Siddens LK, Maier ML, Williams DE, Smith JN, Tilton SC Building a predictive model for polycyclic aromatic hydrocarbon dosimetry in organotypically cultured human bronchial epithelial cells using benzo[ a]pyrene Toxicology Reports 2025 PubMed PMC12517105
Colvin VC, Owiti NA, Engelward BP, Tilton SC Utilization of the CometChip assay for detecting PAH-induced DNA bulky adducts in a 3D primary human bronchial epithelial cell model Toxicology 2025 PubMed PMC12356187
2024
Valdez RM, Rivera BN, Chang Y, Pennington JM, Fischer KA, Löhr CV, Tilton SC Assessing susceptibility for polycyclic aromatic hydrocarbon toxicity in an in vitro 3D respiratory model for asthma. Front Toxicol 2024 PubMed PMC11066177
Colvin VC, Bramer LM, Rivera BN, Pennington JM, Waters KM, Tilton SC Modeling PAH Mixture Interactions in a Human In Vitro Organotypic Respiratory Model. Int J Mol Sci 2024 PubMed PMC11050152
2023
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 2023 PubMed PMC10782561
Rude CI, Tidwell LG, Tilton SC, Waters KM, Anderson KA, Tanguay RL Coupling Environmental Whole Mixture Toxicity Screening with Unbiased RNA-Seq Reveals Site-Specific Biological Responses in Zebrafish. Toxics 2023 PubMed PMC10053777
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. Toxicol Appl Pharmacol 2023 PubMed PMC9946811
2022
Rivera BN, Ghetu CC, Chang Y, Truong L, Tanguay RL, Anderson KA, Tilton SC Leveraging Multiple Data Streams for Prioritization of Mixtures for Hazard Characterization. Toxics 2022 PubMed PMC9699527
Rivera BN, Wilson LB, Kim DN, Pande P, Anderson KA, Tilton SC, Tanguay RL A Comparative Multi-System Approach to Characterizing Bioactivity of Commonly Occurring Chemicals. Int J Environ Res Public Health 2022 PubMed PMC8998123
Maier ML, Siddens LK, Pennington JM, Uesugi SL, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [(14)C]-BaP. Environ Int 2022 PubMed PMC8791557
2021
Maier ML, Siddens LK, Uesugi SL, Choi J, Leonard SW, Pennington JM, Tilton SC, Smith JN, Ho E, Chow HS, Nguyen BD, Kolluri SK, Williams DE 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. Drug Metab Dispos 2021 PubMed PMC8407664
Chang Y, Rager JE, Tilton SC Linking Coregulated Gene Modules with Polycyclic Aromatic Hydrocarbon-Related Cancer Risk in the 3D Human Bronchial Epithelium. Chem Res Toxicol 2021 PubMed PMC8560124
2020
Chang Y, Huynh CT, Bastin KM, Rivera BN, Siddens LK, Tilton SC Classifying polycyclic aromatic hydrocarbons by carcinogenic potency using in vitro biosignatures. Toxicol In Vitro 2020 PubMed PMC7572825
Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL Aryl Hydrocarbon Receptor Mediates Larval Zebrafish Fin Duplication Following Exposure to Benzofluoranthenes. Toxicol Sci 2020 PubMed PMC7357178
2019
Chang Y, Siddens LK, Heine LK, Sampson DA, Yu Z, Fischer KA, Löhr CV, Tilton SC Comparative mechanisms of PAH toxicity by benzo[a]pyrene and dibenzo[def,p]chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol 2019 PubMed PMC6708476
Brown JM, Phillips AR, Lewis DA, Mans M, Chang Y, Tanguay RL, Peterson ES, Waters KM, Tilton SC Bioinformatics Resource Manager: a systems biology web tool for microRNA and omics data integration. BMC Bioinformatics 2019 PubMed PMC6525352
Madeen EP, Siddens LK, Uesugi SL, Mcquistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene TJ, Turteltaub KW, Williams DE Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 2019 PubMed PMC6369707
2018
Garcia GR, Shankar P, Dunham CL, Garcia A, Ladu JK, Truong L, Tilton SC, Tanguay RL Signaling Events Downstream of AHR Activation That Contribute to Toxic Responses: The Functional Role of an AHR-Dependent Long Noncoding RNA (slincR) Using the Zebrafish Model. Environ Health Perspect 2018 PubMed PMC6371766
Geier MC, Minick DJ, Truong L, Tilton SC, Pande P, Anderson KA, Teeguarden JG, Tanguay RL Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol 2018 PubMed PMC6087484
Hummel JM, Madeen EP, Siddens LK, Uesugi SL, Mcquistan TJ, Anderson KA, Turteltaub KW, Ognibene TJ, Bench G, Krueger SK, Harris S, Smith JN, Tilton SC, Baird WM, Williams DE Pharmacokinetics of [(14)C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food Chem Toxicol 2018 PubMed PMC5935529
2017
Curtis LR, Bravo CF, Bayne CJ, Tilton F, Arkoosh MR, Lambertini E, Loge FJ, Collier TK, Meador JP, Tilton SC Transcriptional changes in innate immunity genes in head kidneys from Aeromonas salmonicida-challenged rainbow trout fed a mixture of polycyclic aromatic hydrocarbons. Ecotoxicol Environ Saf 2017 PubMed PMC7039304
2015
Goodale BC, La Du JK, Tilton SC, Sullivan CM, Bisson WH, Waters KM, Tanguay RL Ligand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs. Toxicol Sci 2015 PubMed PMC4612346
Siddens LK, Bunde KL, Harper TA, Mcquistan TJ, Löhr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol 2015 PubMed PMC4689210
Tilton SC, Siddens LK, Krueger SK, Larkin AJ, Löhr CV, Williams DE, Baird WM, Waters KM Mechanism-Based Classification of PAH Mixtures to Predict Carcinogenic Potential. Toxicol Sci 2015 PubMed PMC4476464
2014
Chen J, Tanguay RL, Tal TL, Gai Z, Ma X, Bai C, Tilton SC, Jin D, Yang D, Huang C, Dong Q Early life perfluorooctanesulphonic acid (PFOS) exposure impairs zebrafish organogenesis. Aquat Toxicol 2014 PubMed PMC4159678
2013
Franzosa JA, Bugel SM, Tal TL, Ladu JK, Tilton SC, Waters KM, Tanguay RL Retinoic acid-dependent regulation of miR-19 expression elicits vertebrate axis defects. FASEB J 2013 PubMed PMC3834785
Goodale BC, Tilton SC, Corvi MM, Wilson GR, Janszen DB, Anderson KA, Waters KM, Tanguay RL Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish. Toxicol Appl Pharmacol 2013 PubMed PMC4098828
Saili KS, Tilton SC, Waters KM, Tanguay RL Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17β-estradiol in embryonic zebrafish. Reprod Toxicol 2013 PubMed PMC3690774
Larkin AJ, Siddens LK, Krueger SK, Tilton SC, Waters KM, Williams DE, Baird WM Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin. Toxicol Appl Pharmacol 2013 PubMed PMC3626406
Truong L, Tilton SC, Zaikova T, Richman E, Waters KM, Hutchison JE, Tanguay RL Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Nanotoxicology 2013 PubMed PMC3399027
2012
Chen J, Huang C, Truong L, Ladu JK, Tilton SC, Waters KM, Lin K, Tanguay RL, Dong Q Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. Toxicology 2012 PubMed PMC3511642
Tilton SC, Tal TL, Scroggins SM, Franzosa JA, Peterson ES, Tanguay RL, Waters KM Bioinformatics Resource Manager v2.3: an integrated software environment for systems biology with microRNA and cross-species analysis tools. BMC Bioinformatics 2012 PubMed PMC3534564
Siddens LK, Larkin AJ, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Löhr CV, Arlt VM, Phillips DH, Williams DE, Baird WM Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol 2012 PubMed PMC3483092