The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor.

Publication Type:
Journal Article
Year of Publication:
Journal:
PLoS One
Date Published:
Abstract:

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity and biological activity of dioxins and related chemicals. The AhR influences a variety of processes involved in cellular growth and differentiation, and recent studies have suggested that the AhR is a potential target for immune-mediated diseases.

DOI:
10.1371/journal.pone.0013128
PubMed ID:
20957046
PubMed Central ID:
PMC2948512
Funding Sources
1F31CA144571-01
P30 ES00210
R01 ES016651
ES016651
T32ES07060
P42 ES016465
F31 CA144571
T32 ES007060
P30 ES000210