Cord blood DNA methylation of DNMT3A mediates the association between in utero arsenic exposure and birth outcomes: Results from a prospective birth cohort in Bangladesh.

Publication Type:
Journal Article
Year of Publication:
Journal:
Environ Res
Date Published:
Abstract:

Fetal epigenetic programming plays a critical role in development. DNA methyltransferase 3 alpha (DNMT3A), which is involved in de novo DNA methylation (DNAm), is a prime candidate gene as a mediator between prenatal exposures and birth outcomes. We evaluated the relationships between in utero arsenic (As) exposure, birth outcomes, and DNMT3A DNAm.

DOI:
10.1016/j.envres.2020.109134
PubMed ID:
32018205
PubMed Central ID:
PMC7167334
Funding Sources
F31 ES029019
P42 ES010349
R01 ES015533
P42 ES016465
TL1 TR001875
R01 ES023441