Americans spend approximately 90% of their time indoors, with more than 66% of that time spent in residential buildings. Factors pertaining to household behavior or environmental factors may influence types of semi-volatile organic compounds (SVOC) found indoors. Paired indoor and outdoor passive samplers were deployed at twenty-four locations across the United States. Samples were analyzed for >1500 SVOCs to identify common patterns in exposure profiles and investigate influences of household behavior and environmental factors. Unique differences between indoor and outdoor profiles were identified, with indoor air typically having greater frequency and concentration of SVOCs relative to outdoor air. A significant relationship between fragrance chemicals and scented consumer products was identified. When considering a multifactorial approach, chemical exposures were most influenced by environmental and demographic factors. Our data highlights specific groups of chemicals identified at higher concentrations indoors and their potential influences, as well as the complexity of identifying specific sources of chemical exposures.
