Tanguay’s group exposed zebrafish embryos to seven different types of TAML activators. None of the TAML’s impaired embryo development at concentrations typically used for decontaminating water.
The collaboration resulted in a new journal publication in Green Chemistry.
These are important findings that contribute toward TAML activators getting commercialized for water treatment.
Endocrine disruptors and human health
Endocrine disruptors can disrupt normal functions of the endocrine system and impair development, by mimicking or blocking the activities of hormones in wildlife. Several animal studies suggest that endocrine disruptors can also affect human health, and may be involved in cancers, learning disabilities, obesity, and immune and reproductive system disorders.
Robyn Tanguay’s leadership in utilizing zebrafish
Robyn Tanguay is Director of the Sinnhuber Aquatic Research Laboratory, which is the largest zebrafish toxicology lab in the world.
In 2012, Dr. Tanguay received an EPA grant award, “Toxicity Screening with Zebrafish Assay”. The award is for three years and almost two million dollars in funding to examine the developmental toxicology of at least 1000 chemicals.
Dr. Tanguay and her research team have tested over 3,000 compounds of interest to the National Toxicology Program (NTP), to complement the ongoing high-throughput screening efforts in the U.S. government’s multiagency Tox21 research program.
Citation: Truong L, DeNardo MA, Kundu S, Collins TJ, Tanguay RL. 2013. Zebrafish assays as developmental toxicity indicators in the green design of TAML oxidation catalysts. Green Chem; doi:10.1039/C3GC40376A [Online 15 July 2013].