Friday, October 7, 2022

Arsenic exposure is a global public health problem. Arsenic is a multi-organ toxicant and chronic exposure causes multiple chronic diseases including cancer. Skin cancer is the most common cancer caused by arsenic exposure but the mechanism(s) of carcinogenesis remain unclear. This presentation focuses on dysregulation of RNA metabolism in an in vitro model of skin carcinogenesis by chronic low level arsenic exposure. Dysregulated expression of microRNA and mRNAs and alternative mRNA splicing and the intersection with chromosomal instability will be discussed.