Jordan Smith

Core Leader

Jordan Smith studies the biological fate of chemicals and implications of chemical exposures on human health. He applies advanced molecular tools, cell-based models, in vivo techniques, and computational tools to understand how absorption, distribution, metabolism, and excretion processes affect dosimetry of chemicals and mediate toxicity. His research contributions continue to expand our understanding of life-stage susceptibility to chemicals, non-invasive biomonitoring, target-tissue dosimetry, and biological fate of nanomaterials.

Associated Research

Predictive Dosimetry and Metabolism Core

External Profile

Pacific Northwest National Laboratory

Recent Superfund Publications

2025

Colvin VC, Bastin KM, Siddens LK, Maier ML, Williams DE, Smith JN, Tilton SC Building a predictive model for polycyclic aromatic hydrocarbon dosimetry in organotypically cultured human bronchial epithelial cells using benzo[ a]pyrene Toxicology Reports 2025 PubMed PMC12517105

Gaither KA, Tyrrell KJ, Garcia WL, Anderson KA, Smith JN Human in vitro metabolism of an environmental mixture of polycyclic aromatic hydrocarbons (PAH) found at the Portland Harbor Superfund Site Toxicology Letters 2025 PubMed

Rude CI, Smith JN, Scott RP, Schultz KJ, Anderson KA, Tanguay RL A mixture parameterized biologically based dosimetry model to predict body burdens of polycyclic aromatic hydrocarbons in developmental zebrafish toxicity assays. Toxicol Sci 2025 PubMed PMC12118961

2024

Rude CI, Wilson LB, Ladu JK, Lalli PM, Colby SM, Schultz KJ, Smith JN, Waters KM, Tanguay RL Aryl hydrocarbon receptor-dependent toxicity by retene requires metabolic competence. Toxicol Sci 2024 PubMed PMC11514837

Gaither KA, Garcia WL, Tyrrell KJ, Wright AT, Smith JN Activity-Based Protein Profiling to Probe Relationships between Cytochrome P450 Enzymes and Early-Age Metabolism of Two Polycyclic Aromatic Hydrocarbons (PAHs): Phenanthrene and Retene. Chem Res Toxicol 2024 PubMed

2023

Maier ML, Siddens LK, Pennington JM, Uesugi SL, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 2023 PubMed PMC10782561

Maier ML, Siddens LK, Pennington JM, Uesugi SL, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. Toxicol Appl Pharmacol 2023 PubMed PMC9946811

2022

Smith JN, Gaither KA, Pande P Competitive Metabolism of Polycyclic Aromatic Hydrocarbons (PAHs): An Assessment Using In Vitro Metabolism and Physiologically Based Pharmacokinetic (PBPK) Modeling. Int J Environ Res Public Health 2022 PubMed PMC9323266

Garcia WL, Miller CJ, Lomas GX, Gaither KA, Tyrrell KJ, Smith JN, Brandvold KR, Wright AT Profiling How the Gut Microbiome Modulates Host Xenobiotic Metabolism in Response to Benzo[a]pyrene and 1-Nitropyrene Exposure. Chem Res Toxicol 2022 PubMed PMC9878584

Pande P, Madeen EP, Williams DE, Crowell SR, Ognibene TJ, Turteltaub KW, Corley RA, Smith JN Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol 2022 PubMed PMC9264404